Disorders of the autonomic nervous system.

FURTHER READINGS Bosco D et al: Wild-type and mutant SOD1 share an aberrant conformation and a common pathogenic pathway in ALS. Nat Neurosci, 11:1396, 2010 Bruijn LI, Cudkowicz M: Therapeutic targets for amyotrophic lateral sclerosis: Current treatments and prospects for more effective therapies. Expert Rev Neurother 6:417, 2006 Digiorgio et al: Non-cell autonomous effect of glia on motor neurons in an embryonic stem cell-based ALS model. Nat Neurosci 10:608, 2007 Dion PA et al: Genetics of motor neuron disorders: New insights into pathogenic mechanisms. Nat Genet 10:769, 2009 Fink JK: Hereditary spastic paraplegia. Curr Neurol Neurosci Rep 6:65, 2006 Foust K et al: Rescue of the spinal muscular atrophy phenotype in a mouse model by early postnatal delivery of SMN. Nat Biotechnol 28:271, 2010 Kiernan MC et al: Amyotrophic lateral sclerosis. Lancet 377:942, 2011 Kwiatkowski T et al: Mutations in a novel ALS gene. Science 323:1205, 2009 Lagier-Tourenne C et al: TDP-43 and FUS/TLS: Emerging roles in RNA processing and neurodegeneration. Hum Mol Gen 19:R46, 2010 Mckee AC et al: TDP-43 Proteinopathy and motor neuron disease in chronic traumatic encephalopathy. J Neuropathol Exp Neurol 69:918, 2010 Smith RA et al: Antisense oligonucleotide therapy for neurodegenerative disease. J Clin Invest 116:2290, 2006 Weisskopf MG et al: Prospective study of military service and mortality from ALS. Neurology 64:32, 2005